IBM System x Enterprise Servers in the New Enterprise Data Center
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Fast-tracking C010DS-Zn: PARP1-agonist targeting cancer and M2-like macrophages
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Type: Talk
Parthanatos (a programmed necrosis from PARP1 hyperactivation) is an untapped death mechanism in oncology, and it offers some ideal features for cancer treatments including immunogenicity and its independence from the drug resistance-ridden p53-apoptosis pathway. Xylonix has developed several synthetic peptide-conjugate APIs including C005D-Zn, C008D-Zn, and C010DS-Zn that were designed to induce parthanatos in cancer, and to varying degrees, M2-like macrophages (M2) with increasing cytotoxicity to both targets in higher-numbered agents. Previously known as the pro-tumor immunity that hampered cancer immunotherapy advances, M2 was also discovered to play the central role in generating both the acute severe cytokine storm and long-term thrombotic complications of COVID19. In the context of the pandemic Xylonix is now focusing to fast-track the C010DS-Zn development with its first target in-human trials against COVID19 with subsequent expansions into oncology and other M2-driven autoimmune diseases. In this talk, I share Xylonix strategy and some breakthrough data for supporting such development goals via aggressive utilization of mechanism studies, genomic information, and large-scale screenings.
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The server buyer's playbook
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Agility is Funding and Developing Warehouse Parks for Lease Across Africa
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Agility is a pioneer in emerging markets and one of the largest private owners and developers of warehousing and light industrial parks in the Middle East and Africa region and owns and operates over 21 million m2 of logistics parks around the world. Agility warehouses provide an international standard infrastructure platform that supports companies doing business in Africa, enabling them to access the burgeoning African market faster and more efficiently, and to operate in Africa without having to fund or develop their own infrastructure. Agility warehouse parks in Africa deliver ready built quality warehouses that create a platform that supports imports, exports and local production. Customers can sign a lease and move in immediately. All warehouses are secure within a site perimeter wall with consistent power and IT connectivity, creating an enabling environment where our tenants can focus on their business whilst we manage the operational infrastructure. Agility warehouse parks offer bonded and non-bonded warehouse spaces, racked units, warehouse showrooms and open yards. Agility warehouses are leased for storage, distribution, packaging, processing, ecommerce and light manufacturing. Warehouses for lease start from 1,000 m2 upwards, and flexible, so units can be expanded and added to or reduced dependent on customers requirements. Agility also funds and develops built-to-suit bespoke buildings to meet specific customer demands for cold stores, data centres, life science and other requirements. https://www.agility.com/en/logistics-parks/
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Introduction to Google Threat Intelligence
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