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This document provides a reference architecture and design guide for up to 5000 seat mixed workload on Cisco UCS and Pure Storage FlashArray//m with Citrix XenApp server-based sessions, XenDesktop persistent Windows 10 virtual desktops and XenDesktop pooled Windows 10 virtual desktops on VMware vSphere 6. The solution is a predesigned, best-practice data center architecture built on the Cisco Unified Computing System (UCS), the Cisco Nexus® 9000 family of switches, Cisco MDS 9000 family of Fibre Channel switches and Pure Storage all flash array.