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With all the web-connected ways your organization does business, you have to be ready to handle malware attacks, multiplying threat vectors, and increased compliance responsibilities. Threat protection requires an updated approach now that the classic model of anti-virus plus firewall is no longer enough. Current best practice calls for interlocking layers of protection that support your company’s business processes and the digital assets you need to protect. This paper describes principles you can use to strike the best balance between enabling your business and ensuring effective security.